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Polydentate aminodiphosphinates
Böhmová, Zuzana ; Kubíček, Vojtěch (advisor) ; Vojtíšek, Pavel (referee)
Two linear aminodiphosphinates (H3L1 , H5L2 ) and one cyclic aminodiphosphinate (H2L3 ) were prepared and studied. Newly prepared compounds were characterized by NMR, MS and EA (elemental analysis). Acid-base and coordination properties of ligands were studied. Protonation constants and stability constants of complexes with Zn2+ , Ni2+ and Cu2+ metal ions were determined by potentiometry. Keywords Ligands, dissociation constants, potentiometry, phosphinates, complexes.
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New ligands for magnetic resonance imaging; pH-sensitive probes
Táborská, Zdeňka ; Kotek, Jan (advisor) ; Kubíček, Vojtěch (referee)
TÁBORSKÁ, Z. New ligands for magnetic resonance imaging; pH-sensitive probes. Prague: Charles University in Prague, Faculty of Science, Department of Inorganic Chemistry, 2011, 32 pages. Supervisor: doc. RNDr. Kotek J., Ph.D. Magnetic resonance imaging is a modern method used in diagnostic for assessing morphology and pathology of soft tissues. This thesis briefly outlines the principles of magnetic resonance imaging, including instrumentation. In many cases intravenously administered contrast agents are used, which are used for diagnostic purposes. At present, the most applied are CAs based on Gd(III) complexes. The experimental part of the thesis is focused on preparation of a derivative of DTPA with aminomethylphosphinate pendant group for using as a potential ligand for CAs for the magnetic resonance imaging. KEYWORDS: magnetic resonance imaging, contrast agents, lanthanides, phosphinates
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Phosphonate and phosphinate derivatives of dipicolylamine
Hlinová, Veronika
The Diploma Thesis deals with preparation of one phoshonate and two phospinate derivatives of dipicolylamine. Dissociation constants of prepared ligands were determined by potentiometric and NMR titration. Coordination properties of the compounds were studied by combination of potentiometry and UV-VIS spectrophotometry. Stability constants of complexes with selected transition metal ions (Cu2+ , Ni2+ a Zn2+ ) and alkali-earth metals ions (Ca2+ , Mg2+ ) were calculated. Acid-base and coordination properties in the solid state were studied by X-ray diffraction on single-crystals.
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Phosphonate and phosphinate derivatives of dipicolylamine
Hlinová, Veronika
The Diploma Thesis deals with preparation of one phoshonate and two phospinate derivatives of dipicolylamine. Dissociation constants of prepared ligands were determined by potentiometric and NMR titration. Coordination properties of the compounds were studied by combination of potentiometry and UV-VIS spectrophotometry. Stability constants of complexes with selected transition metal ions (Cu2+ , Ni2+ a Zn2+ ) and alkali-earth metals ions (Ca2+ , Mg2+ ) were calculated. Acid-base and coordination properties in the solid state were studied by X-ray diffraction on single-crystals.
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Phosphonate and phosphinate derivatives of dipicolylamine
Hlinová, Veronika ; Kubíček, Vojtěch (advisor) ; Vojtíšek, Pavel (referee)
The Diploma Thesis deals with preparation of one phoshonate and two phospinate derivatives of dipicolylamine. Dissociation constants of prepared ligands were determined by potentiometric and NMR titration. Coordination properties of the compounds were studied by combination of potentiometry and UV-VIS spectrophotometry. Stability constants of complexes with selected transition metal ions (Cu2+ , Ni2+ a Zn2+ ) and alkali-earth metals ions (Ca2+ , Mg2+ ) were calculated. Acid-base and coordination properties in the solid state were studied by X-ray diffraction on single-crystals.
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Polydentate aminodiphosphinates
Böhmová, Zuzana ; Kubíček, Vojtěch (advisor) ; Vojtíšek, Pavel (referee)
Two linear aminodiphosphinates (H3L1 , H5L2 ) and one cyclic aminodiphosphinate (H2L3 ) were prepared and studied. Newly prepared compounds were characterized by NMR, MS and EA (elemental analysis). Acid-base and coordination properties of ligands were studied. Protonation constants and stability constants of complexes with Zn2+ , Ni2+ and Cu2+ metal ions were determined by potentiometry. Keywords Ligands, dissociation constants, potentiometry, phosphinates, complexes.
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